Moderate alcohol consumption increases oxidative stress in patients with chronic hepatitis C

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Moderate alcohol consumption increases oxidative stress in patients with chronic hepatitis C.

The mechanisms by which alcohol consumption worsens the evolution of chronic hepatitis C (CHC) are poorly understood. We have investigated the possible interaction between hepatitis C virus (HCV) and ethanol in promoting oxidative stress. Circulating IgG against human serum albumin (HSA) adducted with malondialdehyde (MDA-HSA), 4-hydroxynonenal (HNE-HSA), or arachidonic acid hydroperoxide (AAHP...

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Moderate, excessive or heavy alcohol consumption: each is significantly associated with increased mortality in patients with chronic hepatitis C.

BACKGROUND The impact of moderate alcohol consumption on long-term outcomes of chronic hepatitis C (CH-C) infected patients remains controversial. AIM To assess the impact of moderate alcohol consumption on long-term outcomes of CH-C patients using population-based data. METHODS Data were obtained from the Third National Health and Nutrition Examination Survey (NHANES III)-mortality linked ...

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Antioxidant supplementation attenuates oxidative stress in chronic hepatitis C patients.

UNLABELLED Reactive oxygen species (ROS) overgeneration is involved in the pathogenesis of hepatitis C. The aim of this study was to evaluate the antioxidant status in the blood of HCV infected patients treated or not with standard therapy before and after supplementation of vitamins E, C and zinc. Biomarkers of oxidative stress were evaluated in the blood of three groups of patients: group 1 -...

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[Oxidative stress in patients with chronic hepatitis B].

BACKGROUND To study oxidative stress in patients with chronic hepatitis B. METHODS Malondialdehyde (MDA), total anti-oxidative ability and ascorbic acid were measured as markers of oxidative stress in 30 patients with chronic hepatitis B, besides HBV DNA and ALT. RESULTS MDA was significantly higher in patients with hepatitis B than the controls (P less than 0.05). Ascorbic acid was signifi...

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Cryoglobulinemia in patients with hepatitis C

Introduction: Cryoglobulinemia is a kind of immunoglobuline that form in various conditions. These imunoglobulines, precipitate in cold environment and restore to soluble state upon rewarming. Nowadays, strong association between cryoglobulines and hepatitis C has been proposed. Methods: This is a descriptive-analytic study in which we included all documented cases of hepatitis C infection wh...

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ژورنال

عنوان ژورنال: Hepatology

سال: 2003

ISSN: 0270-9139

DOI: 10.1053/jhep.2003.50275